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Morphological and Biomechanical Insights into the Pathophysiology of Femoroacetabular Impingement Syndrome

US · IL NIH grant awarded #nih-5R01AR077636-05

Summary

This research project aims to advance the understanding of Femoroacetabular Impingement Syndrome (FAIS) pathophysiology by examining hip anatomy and biomechanics using experimental (dual fluoroscopy) and computational (finite element modeling) techniques across FAIS patients, negative controls, and positive controls.

What they want

The project will examine three cohorts: FAIS patients, negative controls, and positive controls. Aim 1 involves measuring in-vivo hip articulation during inclined walking, pivoting, and squatting using dual fluoroscopy, followed by visualizing the interaction between hip joint shape and kinematic position during dynamic loading using statistical shape modeling. Aim 2 will analyze chondrolabral mechanics in-silico by generating finite element models of bone, cartilage, and labrum, comparing load transfer to the labrum and shear stresses/strains at the osteochondral and chondrolabral junctions during specific movements, and quantifying relationships between local hip shape measures and chondrolabral mechanics.
Deliverables
  • Improved clinical understanding of FAIS through visualization of pathologic shape effects during dynamic loading
  • Enhanced understanding of OA pathogenesis in FAIS patients
  • Identification of coping mechanisms in positive controls to inform new treatment strategies
  • Quantitative understanding of FAIS disease
  • Measurements of in-vivo hip articulation
  • Statistical shape models of hip joint interaction
  • Finite element models of bone, cartilage, and labrum
  • Analysis of load transfer, shear stresses, and strains in chondrolabral mechanics
  • Quantified relationships between hip shape and chondrolabral mechanics
Technical requirements
  • Dual fluoroscopy for in-vivo hip articulation measurement
  • Statistical shape modeling of dual fluoroscopy data
  • Finite element modeling (FEM) of bone, cartilage, and labrum
  • Validated pipeline for FEM generation
  • Analysis of load transfer, shear stresses, and strains at osteochondral and chondrolabral junctions

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Morphological and Biomechanical Insights i…
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