Summary
Pulmonary Hypertension (PH) is a fatal disease where abnormal cells termed “neointima” progressively occlude the pulmonary arteries leading to debilitating right heart failure. PH pathology is characterized by perivascular inflammation, including T cell rich Tertiary Lymphoid Follicles (TLFs). Although perivascular inflammation associates with worse outcomes, preclinical studies implicate T cells as having both pathogenic and protective roles in PH. A repertoire of helper (Th) and regulatory (TReg) T cells shape the immune response by sensing antigen via their T cell Receptors (TCRs) and clona
