Summary
Abstract While antifibrotic therapies continue to advance, they fall short when treating large or chronic wounds. Essential to developing new regenerative strategies is a comprehensive understanding of how cell proliferation is activated, maintained, and eventually terminated to accurately restore missing tissue. The objective of this proposal is to determine the cell autonomous mechanisms that permit and control proliferation during complex tissue regeneration in highly regenerative mammals (spiny mice and rabbits). Spiny mice are unique among rodents in their ability to regenerate complex s
