Summary
PROJECT SUMMARY: Neurodegenerative diseases pose significant challenges to public health and our understanding of brain function. Central to these conditions is the pathological accumulation of protein aggregates, notably alpha-synuclein, beta- amyloid, and Tau. Specifically, Tau aggregates are expelled into the extracellular space as neurons degenerate, where they act as damage-associated molecular patterns (DAMPs) that are sensed by microglia. Microglial activation leads to inflammatory responses, which contribute to impaired neuronal function and cognitive decline in diseases like Alzheimer
