Summary
The collapse of the World Trade Center on September 11, 2001 resulted in the massive release of dust, gas, and fumes with potential exposure to known and suspected carcinogens for thousands of individuals. Historically, most of the research focused on first-responders. However, the impact of the WTC exposures on general population, particularly on the health of younger people and women remains poorly understood. The current application will focus on WTC-exposed non- responder women who were diagnosed with breast cancer. The epigenome acts as an interface between the genome and the environment.