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Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-158
Response due Nov 17, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting research grant applications under the R61/R33 phased innovation award mechanism focused on prevention and intervention approaches for Fetal Alcohol Spectrum Disorders (FASDs). The R61 phase supports milestone-driven developmental/exploratory research, while the R33 phase supports expanded research following successful completion of R61 milestones. Clinical trials are optional under this funding opportunity announcement (FOA). The opportunity is open from November 2024 through November 2026, allowing multiple submission cycles.

What they want

Applicants must propose research projects targeting the prevention of and/or intervention for Fetal Alcohol Spectrum Disorders (FASDs). The phased R61/R33 structure requires: (1) R61 phase — exploratory/developmental research with defined milestones that must be achieved before transition to R33; (2) R33 phase — expanded implementation of the research following successful R61 milestone completion. Clinical trials are permitted but not required. Research may address behavioral, biomedical, or other prevention/intervention strategies relevant to FASDs.
Technical requirements
  • Phased R61/R33 application structure with defined milestones for R61 phase transition
  • Clinical trial inclusion is optional but must be declared at time of application
  • Research must address prevention and/or intervention approaches specifically for Fetal Alcohol Spectrum Disorders (FASDs)
  • R61 milestones must be met before advancement to R33 phase

How they evaluate

Submission: Electronic submission via Grants.gov and/or NIH eRA Commons portal

Risks & flags

  • Minimal detail provided in the source text — full FOA (PAR-25-158) should be reviewed on NIH Guide for full eligibility, budget caps, and review criteria
  • Long open window (2 years) suggests multiple receipt dates; exact submission deadlines require verification in the full FOA

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Prevention and Intervention Approaches for…
Due Nov 17
Onboard ↗