Summary
Development of a telemetric regenerative bandage system to accelerate wound healing in diabetic foot ulcers by combining an antioxidant, tissue-regenerating dressing with wireless sensors for real-time monitoring of temperature and pH.
Telemetric Regenerative Bandage for Accelerating Wound Healing
US · IL
NIH
grant
awarded
#nih-5R01DK131302-05
What they want
The project aims to develop a versatile wound dressing that restores normal wound healing rates by reducing free radicals, providing a scaffold for cell division and migration, and enhancing vascularization. Concurrently, it will develop a wireless system with tissue-conforming sensors to monitor wound temperature and pH in real time, which are indicators of infection. The overall goal is to create a shape-conforming antioxidant dressing (PPCN-A5G81 with immobilized Cu2+) that promotes new tissue formation and a feedback system with sensors to monitor bacterial infection and healing progress in diabetic wounds.
Deliverables
- Fabrication of a PPCN-based regenerative dressing with vasculoinductive, dermoconductive, and dermoinductive properties
- Investigation of safety and efficacy of the dressing for healing full thickness wounds in diabetic mice and diabetic pigs with metabolic syndrome
- Fabrication and characterization of telemetric wound feedback tissue-conforming sensors capable of measuring temperature and pH in infected and non-infected diabetic dermal wounds
Technical requirements
- Development of poly (polyethylene glycol citrate-co-N isopropyl acrylamide) (PPCN-A5G81) macromolecule incorporating a laminin-derived peptide
- Incorporation of immobilized Cu2+ into PPCN-A5G81 for vasculoinductive properties
- Flexible, stretchable electronic sensors for continuous, non-invasive health monitoring
- Sensors capable of measuring temperature and pH wirelessly
