Summary
PRECISION AGING NETWORK: CLOSING THE GAP BETWEEN COGNITIVE HEALTHSPAN ANDHUMAN LIFESPAN - SUMMARY/ABSTRACT: OVERALL PROJECT THE STRATEGIC VISION OF THE PRECISION AGING NETWORK (PAN) IS TO DEVELOP THE ESSENTIAL SCIENTIFIC KNOWLEDGE TO UNDERSTAND THE DISCREPANCY THAT CURRENTLY EXISTS BETWEEN COGNITIVE HEALTHSPAN AND HUMAN LIFESPAN. WE MUST REVEAL THE NEURAL MECHANISMS THAT 1) ACCOUNT FOR OPTIMAL BRAIN PERFORMANCE IN OLD AGE RESULTING IN HEALTHY COGNITIVE FUNCTION, AND 2) THOSE THAT UNDERLIE DECLINE IN BRAIN FUNCTION LEADING TO AGE-RELATED COGNITIVE IMPAIRMENT (ARCI), ALZHEIMER’S DISEASE (AD), OR ALZHEIMER’S DISEASE-RELATED DEMENTIAS (ADRD). THE ULTIMATE GOAL OF THE PAN IS TO DEVELOP NOT ONLY A STRONG SCIENTIFIC FOUNDATION FOR THE ESSENTIAL KNOWLEDGE NEEDED TO MATCH COGNITIVE HEALTHSPAN WITH HUMAN LIFESPAN, BUT ALSO TO LEVERAGE BIG DATA APPROACHES THAT APPLY PRECISION MEDICINE CONCEPTS TO PROLONG OPTIMAL BRAIN FUNCTION. TO ACHIEVE THIS GOAL OF SUSTAINING OPTIMAL COGNITIVE FUNCTION IN OLD
