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Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)

US · MD National Institutes of Health (NIH) grant open #PAR-25-060
Response due Oct 20, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is offering the IGNITE program to fund the development and validation of model systems that facilitate neurotherapeutic discovery. This is a two-phase R61/R33 grant mechanism designed to support early translational research efforts in the neuroscience/neurotherapeutics space. Clinical trials are explicitly excluded from this funding opportunity. The grant is open from October 2024 through October 2027, providing a multi-year window for application submission.

What they want

Awardees will develop and validate model systems intended to facilitate the discovery of neurotherapeutics. The R61 phase supports initial milestone-driven research, and the R33 phase supports expanded development contingent on R61 milestone achievement. Clinical trials are not allowed under this funding opportunity announcement (FOA). Work must advance translational efforts from basic neuroscience toward therapeutic applications.
Technical requirements
  • Proposals must focus on development and validation of model systems for neurotherapeutic discovery
  • Clinical trials are not allowed under this FOA
  • Research must follow R61/R33 phased grant structure with milestone-driven progression
  • Work must be translational in nature, bridging basic neuroscience and therapeutic applications

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Multi-year open solicitation window (3 years) with rolling submissions may favor well-resourced institutions already in dialogue with NIH program officers
  • Highly specialized scope (neurotherapeutic model systems) may limit competitive field to a small number of qualified research institutions

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Innovation Grants to Nurture Initial Trans…
Due Oct 20
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