Summary
ABSTRACT New and innovative approaches to studying modifiable mechanisms of heart failure are crucial. Heart failure impacts approximately 7 million adults in the United States and has a 5-year mortality rate of 42%. Obstructive sleep apnea (OSA), traditionally assessed by the apnea-hypopnea index (AHI), increases the risk of heart failure. OSA-specific measures of hypoxia (hypoxic burden) and autonomic response (∆heart rate) are associated with heart failure and adverse cardiovascular disease (CVD) outcomes, independent of the AHI. Abnormal left ventricular (LV) myocardial flow reserve, measu
