Summary
Project summary Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Uterine atony, insufficient uterine contractility after placental delivery, causes 80% of PPH. Oxytocin is the medical standard of care for prophylaxis and first line treatment of PPH. However, the mechanism whereby oxytocin causes uterine contractility remains incompletely understood. There is a critical need to determine (1) how oxytocin causes uterine contractility, and (2) the cellular and molecular mechanisms that underlie compromised oxytocin response in uterine atony. Such knowle
