Summary
Project Summary Regulated transcription of genes is essential for cell proliferation, differentiation and viability. Any misregulation may lead to a disease or a developmental abnormality. The transcription cycle of eukaryotic genes consists of multiple steps. The accomplishment of each of these steps requires a number of accessory factors. The initiation of transcription by RNAPII requires gene-specific factors and the general transcription factors (GTFs). The conventional view is that the general transcription factors (GTFs) operate exclusively at the initiation step of transcription. Many r
