Summary
Project Summary Tick-borne Powassan virus (POWV) is an emerging public health threat, but has been understudied to date. Since its discovery in 1958, human cases of POWV have been reported in the United States, Canada, and Russia. Starting in 2006, confirmed cases of POWV have increased in both frequency and scope in New England and the Upper Midwest. Notably, POWV is now considered an emerging public health threat because it has been frequently associated with the aggressive, human-biting blacklegged tick vector, Ixodes scapu- laris. The future spread of POWV is unpredictable, but it will be
