NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)

US National Institutes of Health – National Cancer Institute (NCI) grant open #PAR-25-313

Response due Oct 14, 2027 · 00:00 UTC

Summary

The National Cancer Institute (NCI) Pathway to Independence Award (K99/R00) is a federal grant opportunity designed to support outstanding postdoctoral researchers in transitioning to independent research careers. The K99 phase provides mentored research support, while the R00 phase supports independent research. This particular announcement requires a clinical trial component as part of the proposed research. The opportunity is open for a multi-year window spanning from January 2025 through October 2027.

What they want

Technical requirements

Clinical trial required as part of proposed research scope
Must comply with NIH clinical trial policies and reporting requirements
K99 phase: mentored postdoctoral research
R00 phase: independent research

How they evaluate

Submission: Grants.gov electronic submission portal

Eligibility & certifications

SAM registration (for institutional applicants)NIH eRA Commons registrationCompliance with NIH human subjects / clinical trial regulations

Risks & flags

Clinical trial required designation significantly narrows the eligible applicant pool
Multi-year open window (2025–2027) with rolling deadlines not specified in the excerpt — actual submission deadlines may vary by cycle

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NCI Pathway to Independence Award (K99/R00…

Due Oct 14

Onboard ↗