Summary
Research project investigating the gut-brain circuit responsible for rapid sugar sensing and its role in sugar overconsumption, focusing on neuropod cells and sodium-glucose transporters (SGLTs).
Rapid sugar sensing from gut to brain
US · IL
NIH
grant
awarded
#nih-5F30DK136229-03
What they want
The project aims to determine whether specific SGLT activation leads to neuropod cell glutamate release and whether an anti-diabetic molecule causes rapid, neuropod cell-dependent vagal activity.
Technical requirements
- Neurogenetic manipulations of intestinal organoids
- In vitro electrophysiology
- In vivo electrophysiology
