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Signaling mechanisms that modulate uterine 3D structure for pregnancy success

US · IL NIH grant awarded #nih-5R01HD109152-04

Summary

This project investigates embryo and progesterone-driven mechanisms that modulate the 3D structure of the uterus to facilitate embryo implantation and successful pregnancy outcomes.

What they want

The project aims to determine how the embryo affects the 3D structure of the uterus, including the temporal pattern of fold formation and whether the embryo acts as a physical object or a biological signaling center. It will test the hypothesis that progesterone influences endometrial receptivity by shaping uterine 3D structure, assessing human subjects and using mouse models with varying progesterone levels. Additionally, the project will determine if progesterone affects uterine luminal shape by interacting with the WNT5A signaling pathway and if aberrant folding explains poor pregnancy outcomes in specific mutants. The long-term goal is to identify novel uterine 3D structure-based mechanisms governing endometrial receptivity to improve fertility outcomes.
Deliverables
  • Understanding of embryo-driven mechanisms affecting uterine 3D structure
  • Understanding of progesterone's influence on endometrial receptivity and uterine 3D structure
  • Understanding of progesterone-WNT5A pathway interaction in uterine shape
  • Developed methods for 3D uterine structure analysis for implantation-defective conditions
  • Identification of novel molecular and structural pathways for successful implantation
  • Identification of novel uterine 3D structure-based mechanisms governing endometrial receptivity
Technical requirements
  • Confocal imaging
  • 3D image analysis
  • Mouse mutants (progesterone signaling deficient, excess progesterone signaling, WNT5A signaling deficient)
  • Time-course studies
  • Physiological and supra-physiological progesterone treatment
  • Mouse model of superovulation

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

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