Summary
Project Summary/Abstract Neuroendocrine prostate cancer (NEPC) is the most virulent form of the disease. Loss of the tumor suppressors TP53/RB1 is ubiquitous in NEPC, but molecular mechanisms that explain how loss of TP53/RB1 promotes NEPC development are largely unknown. Further, there are no effective therapies for NEPC. Thus, there is a clear need to clarify targetable mechanisms in NEPC so we may develop new treatments. Loss of epithelial differentiation is one critical hallmark of NEPC. We identified specific transcriptional repressors turned on by TP53/RB1 loss that block androgen rece
