Summary
Project Summary / Abstract Substance use disorders (SUDs) afflict 1 in 10 individuals, and opioid overdose deaths have quintupled over the last 20 years. There is a critical need to develop interventions that can reverse or block opioid-induced changes that can reduce relapse in patients with SUD. Our long-term goal is to better understand how drug seeking is increased by drug-induced neural adaptations. Drug reward and craving are encoded in part by the nucleus accumbens (NAc) and one NAc cellular adaptation that may influence opioid seeking is a change in the intrinsic excitability of NAc me
