Summary
This project aims to investigate the molecular mechanisms by which neoplastic-macrophage hybrid cells disseminate in colorectal cancer, focusing on the role of the RUNX1 pathway.
Mechanisms of Neoplastic Hybrid Cell Dissemination in Colorectal Cancer
US · IL
NIH
grant
awarded
#nih-5F31CA271676-04
What they want
The project proposes to first assess the gene expression and phenotypic profiles of hybrid cells in colorectal cancer tumors and peripheral blood to identify characteristics of hybrid cells that successfully disseminate. Additionally, this project will evaluate the functional role of RUNX1 in facilitating enhanced hybrid cell migration and dissemination. Successful completion of these studies will define the molecular underpinnings of neoplastic hybrid cell migration and dissemination and will provide the basis for future exploration of this unique neoplastic subtype as a biomarker for the detection of early metastatic disease and tumor evolution.
Deliverables
- Definition of molecular underpinnings of neoplastic hybrid cell migration and dissemination
- Basis for future exploration of hybrid cells as a biomarker for the detection of early metastatic disease and tumor evolution
Key personnel
- Physician Scientist
Risks & flags
- This document describes a research grant project, not a typical public-sector procurement opportunity (RFP, IFB, RFQ). The information provided details the research scope and objectives rather than requirements for a vendor.
