Summary
PROJECT SUMMARY Major depressive disorder (MDD) is a leading cause of disability, with substantial individual and societal costs. The heterogeneity of MDD and the lack of predictive tools for individualized treatment present significant challenges to effective care. This proposal aims to leverage recent advances in foundation models, a type of artificial intelligence (AI) that has demonstrated remarkable success in natural language processing, to develop a neuroimaging-based tool that can aid in prognostication, treatment stratification, and biotype discovery in MDD. Foundation models are pretrain
