Summary
Research into the role of heme in retinal vascular development and diseases, specifically investigating its interaction with angiogenic signaling pathways to understand and potentially treat vision loss.
The role of heme in retinal vascular development and disease
US · IL
NIH
grant
awarded
#nih-5R01EY034615-04
What they want
The project aims to understand the signaling pathways controlling the growth and integrity of retinal blood vessels, focusing on a novel angiogenic signaling system centered around heme. Specific aims include determining how heme intersects with Notch signaling to control angiogenic tip/stalk selection, assessing if Flvcr2/heme signaling induction can reverse vascular defects and vision changes in mouse models of exudative vitreoretinopathy, and characterizing Flvcr2/heme's role in VEGF-induced angiogenic proliferation and neo-vascularization.
Technical requirements
- New tools to directly manipulate heme in cultured retinal endothelial cells
- Methods to assess heme transport and intracellular trafficking in vitro
- New conditional knock-in and knock-out alleles to manipulate endothelial heme transport in vivo
Market context
inferred from NAICSProfessional, Scientific & Technical Services
NAICS 541714
- US market size
- $2.0T
- Typical award
- $25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP
Sector-level estimate — full code lookup not yet in catalog.
