Role of glucagon-like peptide-1 signaling in mediating sensory-specific satiety

Summary

This project aims to investigate the neuroendocrine mechanisms, specifically the role of glucagon-like peptide-1 (GLP-1) signaling in the brain, that underlie sensory-specific satiety (SSS) and its impact on food intake in a rat model.

What they want

The project will use a novel rat model of SSS to investigate the neural action of glucagon-like peptide-1 (GLP-1). Aim I will investigate the role of GLP-1 receptor (GLP-1R)-expressing cells and preproglucagon (PPG) neurons in the nucleus tractus solitarius (NTS) in controlling SSS. Aim II will characterize the role of bed nucleus of the stria terminalis (BNST) and central amygdala (CeA) to PPG projections during increased intake of an alternative food, exploring how GLP-1 signaling is modulated.

Deliverables

Findings on central GLP-1-mediated mechanisms by which SSS modulates food intake
Characterization of NTS neural populations (GLP-1R-expressing cells and PPG neurons) in controlling SSS
Characterization of BNST/CeA → PPG projections during increased intake of an alternative food

Technical requirements

Novel rat model of SSS
Investigation of neural action of GLP-1
Characterization of neural populations and projections

Market context

inferred from NAICS

R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)

NAICS 541715

US market size: $95B
Typical award: $100K – $50M+

Typical buyers

DoDNSFNIHNASADOE

Commonly required

DCAA-compliant accountingITARCMMC L2