Effect of WASH interventions on population resilience to climate-driven enteric pathogen transmission along a gradient of socio-economic position

Summary

This study aims to measure the impact of integrated Water, Sanitation, and Handwashing (WASH) interventions on climate-driven enteric pathogen transmission among rural Bangladeshi children, analyzing effects across different socio-economic positions.

What they want

The project will utilize serology data for 10 enteric pathogens collected from the entire birth cohort (n=3,831) of an ongoing cluster-randomized trial and from an intensive substudy (~1,500 children) in rural Bangladesh. Researchers will use generalized additive models to assess the effect of WASH interventions on enteric pathogen seroconversion, considering exposure to monsoon season and socio-economic status. Geospatial methods will be employed to extrapolate findings to broader populations in rural Bangladesh to identify vulnerable regions that would benefit most from similar WASH interventions.

Deliverables

Measurement of the effect of an integrated WASH intervention on enteric pathogen seroconversion
Analysis of how WASH intervention effects vary by months of monsoon season exposure and along a gradient of socio-economic position
Identification of vulnerable regions in rural Bangladesh that would benefit most from integrated WASH interventions using geospatial methods

Technical requirements

Serology of 10 enteric pathogens
Generalized additive models
Geospatial methods
Data from an existing cluster-randomized trial (R01AI166671)