Summary
PROJECT SUMMARY The overarching goal of the research presented in this application is to understand how environmental chemicals trigger a deregulation of the epigenome that can resist epigenetic reprogramming in germ cells and therefore can become heritable. Inorganic arsenic (iAs) is a model epigenetic toxicant owing to its well described impact on global DNA hypomethylation coinciding with a reduction in the levels of the universal methyl donor SAM, used towards DNA and histone methylation. iAs is also a chemical with well-established transgenerational epigenetic inheritance effects, produ
