AI-DRIVEN STRUCTURE-ENABLED ANTIVIRAL PLATFORM (ASAP) - PROJECT SUMMARY/ABSTRACT - OVERALL SARS-COV-2 CONTINUES TO CAUSE SEVERE MORBIDITY AND MORTALITY IN THE ONGOING PANDEMIC. FUTURE RNA VIRUS EPIDEMICS AND PANDEMICS ARE INEVITABLE. NEW CLINICAL-TRIAL-READY ANTIVIRALS ARE URGENTLY NEEDED RNA VIRUSES OF PANDEMIC POTENTIAL. COVID-19 HAS FURTHER UNDERSCORED THE NEED FOR EARLY, GLOBAL ACCESS TO CLINIC-READY COMPOUNDS. BEYOND CORONAVIRUSES; FLAVIVIRUSES AND PICORNAVIRUSES ALSO CAUSE FREQUENT AND ONGOING EPIDEMICS WORLDWIDE AND HAVE NO EFFECTIVE THERAPEUTICS. MAINTAINING A PORTFOLIO OF NOVEL, CLINIC-READY THERAPEUTICS ARE CRITICAL FOR OUR FUTURE PANDEMIC PREPAREDNESS. THE AI-DRIVEN STRUCTURE-ENABLED ANTIVIRAL PLATFORM (ASAP) AVIDD CENTER WILL DEVELOP NOVEL CHEMICAL ASSETS THAT HAVE ANTIVIRAL ACTIVITY AGAINST THREE TARGET VIRAL FAMILIES. ASAP WILL LEVERAGE STATE-OF-THE-ART STRUCTURE-ENABLED TECHNOLOGIES CAPABLE OF LEVERAGING RECENT ADVANCES IN AI/ML AND COMPUTATIONAL CHEMISTRY IN IDENTIFYING

Summary

AI-DRIVEN STRUCTURE-ENABLED ANTIVIRAL PLATFORM (ASAP) - PROJECT SUMMARY/ABSTRACT - OVERALL SARS-COV-2 CONTINUES TO CAUSE SEVERE MORBIDITY AND MORTALITY IN THE ONGOING PANDEMIC. FUTURE RNA VIRUS EPIDEMICS AND PANDEMICS ARE INEVITABLE. NEW CLINICAL-TRIAL-READY ANTIVIRALS ARE URGENTLY NEEDED RNA VIRUSES OF PANDEMIC POTENTIAL. COVID-19 HAS FURTHER UNDERSCORED THE NEED FOR EARLY, GLOBAL ACCESS TO CLINIC-READY COMPOUNDS. BEYOND CORONAVIRUSES; FLAVIVIRUSES AND PICORNAVIRUSES ALSO CAUSE FREQUENT AND ONGOING EPIDEMICS WORLDWIDE AND HAVE NO EFFECTIVE THERAPEUTICS. MAINTAINING A PORTFOLIO OF NOVEL, CLINIC-READY THERAPEUTICS ARE CRITICAL FOR OUR FUTURE PANDEMIC PREPAREDNESS. THE AI-DRIVEN STRUCTURE-ENABLED ANTIVIRAL PLATFORM (ASAP) AVIDD CENTER WILL DEVELOP NOVEL CHEMICAL ASSETS THAT HAVE ANTIVIRAL ACTIVITY AGAINST THREE TARGET VIRAL FAMILIES. ASAP WILL LEVERAGE STATE-OF-THE-ART STRUCTURE-ENABLED TECHNOLOGIES CAPABLE OF LEVERAGING RECENT ADVANCES IN AI/ML AND COMPUTATIONAL CHEMISTRY IN IDENTIFYING