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The role of an unusual variant nucleosome in Toxoplasma gondii life cycle

US National Institute of Allergy and Infectious Diseases grant open #nih-1R01AI183372-01A1

Summary

Program Director/Principal Investigator (Last, First, Middle): Sergio Oscar Angel ABSTRACT The parasite Toxoplasma gondii has infected up to one-third of the world’s population and can cause spontaneous abortion, birth defects, neurologic disorders, and ocular complications. T. gondii infects diverse host cells and must adapt to various environmental changes and stress conditions to complete its life cycle. Stress induces differentiation of T. gondii from tachyzoites to bradyzoites, which is facilitated by epigenetic changes in gene expression. Notably, changes in the availability of the meta

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