Summary
Project Summary Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging Many amyloidogenic peptides are implicated in diseases ranging from Alzheimer’s to diabetes to cardiomyopathy. Chaperone proteins such as HSP27 and αB-crystallin serve a protective role by interacting with amyloidogenic peptides to protect against amyloid diseases. However, amyloidogenic peptides such as desmin fragments are susceptible to polymorphism, when the same peptide forms different amyloid secondary structures, and it is not fully understood how this impacts the binding of chaperone proteins. We h
