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Defining the Role of Angiotensin II Type 2 Receptor in Bladder Physiology and Pathophysiology with Mouse Models

US National Institute of Diabetes and Digestive and Kidney Diseases grant open #nih-1F31DK146416-01

Summary

PROJECT SUMMARY The complex communication mechanisms involved in bladder function are not fully understood. Due to this lack of physiological understanding, bladder diseases have remained challenging to treat, resulting in severe detriment to patient quality of life, particularly in the case of interstitial cystitis/bladder pain syndrome (IC/BPS). To address this, I aim to contribute to the ongoing investigation of the role of renin-angiotensin signaling in the bladder to inform future therapeutic strategies. Angiotensin II (Ang II) is the primary effector molecule of the renin-angiotensin sys

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