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Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)

US · MD National Institutes of Health (NIH) — National Institute on Deafness and Other Communication Disorders (NIDCD) grant open #RFA-DC-27-003
Response due Aug 21, 2028 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting R01 research grant applications for the development of transformative non-invasive or minimally invasive technologies capable of imaging the olfactory system across multiple biological scales. This is a federal funding opportunity posted on Grants.gov under RFA-DC-27-003. The opportunity is open from May 2026 through August 2028, suggesting a multi-cycle funding announcement. The "CT Optional" designation indicates clinical trial activity is permitted but not required under this mechanism.

What they want

Applicants must propose research developing novel non-invasive or minimally invasive imaging technologies targeting the olfactory system, spanning multiple scales (e.g., molecular, cellular, tissue, organ, or systems level). The mechanism is R01 (research project grant), with an optional clinical trial component. The solicitation is issued under RFA-DC-27-003, indicating it originates from the National Institute on Deafness and Other Communication Disorders (NIDCD) within NIH.
Technical requirements
  • Technology must be non-invasive or minimally invasive
  • Imaging must target the olfactory system
  • Research must address multiple biological scales
  • Clinical trial component is optional (CT Optional)
  • Must comply with NIH R01 grant application requirements

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Multi-year open window (May 2026 – Aug 2028) is standard for NIH RFAs with multiple receipt dates — not a red flag in isolation
  • Highly specialized scope (olfactory system imaging across scales) narrows the applicant pool significantly, though this is scientifically justified for a targeted RFA

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Transformative Non-Invasive/Minimally Inva…
Due Aug 21
Onboard ↗