Summary
Project Summary/Abstract – Modeling Core The Modeling Core, as part of SCRIPT, aimed to apply machine learning approaches to clinical and -omics data generated by the SCRIPT projects and cores to develop a models of severe pneumonia and identify novel biomarkers and therapeutic targets. Using an iterative systems biology approach, we generated a detailed model, published in Nature, of how severe SARS-CoV-2 pneumonia, in contrast with severe pneumonia due to other pathogens, possesses a peculiar host response pathobiology that explains its propensity to cause prolonged critical illness. Importa
