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The development & pilot implementation of a Cas13a-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settings

US National Institute of Allergy and Infectious Diseases grant open #nih-5K23AI182453-02

Summary

PROJECT SUMMARY Low-resource settings have a high burden of Neisseria gonorrhoeae infection, but insufficient laboratory infrastructure for diagnostic tests and antimicrobial susceptibility determination, leading to syndromic management, which misses a high proportion of cases and results in the overuse of antibiotics. Together, those factors contribute to driving the emergence of antimicrobial resistance (AMR), a global public health threat. Two novel strategies can combine to address those challenges. First, the use of CRISPR-based technology permits the development of low-cost, point-of-car

The development & pilot implementation of …
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