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Role of cardiac clock misalignment in promoting arrhythmias in swine and donor human hearts

US · IL NIH grant awarded #nih-5R01HL174461-02

Summary

This project investigates whether chronic ischemia leads to circadian misalignment in the heart, increasing vulnerability to arrhythmias and sudden cardiac arrest, using swine models and donor human hearts.

What they want

The project aims to establish a diurnal window of arrhythmia vulnerability in swine with chronic LAD stenosis using optical and electrical mapping (Aim 1), investigate cardiac circadian misalignment and test pharmacological realignment in swine (Aim 2), and validate these findings in donor human hearts (Aim 3).
Deliverables
  • Unique insight regarding the impact of circadian misalignment on arrhythmia vulnerability
  • Illumination of opportunities for pharmacological interventions to manage, prevent, or restore the loss of cardiac circadian alignment
  • Attenuation of time-of-day incidence of cardiac arrhythmias and SCA
Technical requirements
  • Optical mapping of ex vivo cardiac slices
  • In vivo electrical mapping of intact hearts
  • Swine model of chronic LAD stenosis
  • Use of donor human hearts
  • Investigation of intracellular calcium-calcineurin signaling
  • Pharmacological circadian realignment

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

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