Summary
Research into targeting a specific microRNA to alleviate Alzheimer's Disease pathobiology by investigating its role in microglial autophagy and amyloid-β clearance.
Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology
US · IL
NIH
grant
open
#nih-5R01AG082113-03
What they want
Detailed investigation into the mechanism of elevated expression of a specific microRNA (miRNA) in Alzheimer's Disease (AD) brains and its functional consequences on microglial autophagy and amyloid-β clearance. This includes determining the mechanism underlying elevated miR expression (Aim 1) and investigating the functional consequences of reducing this miR in AD mouse brains, the mechanism of miR upregulation, and the behavior of microglia from treated mice (Aim 2).
Deliverables
- Characterization of a novel drug target and mode of delivery for AD
Technical requirements
- Use of AD mouse model 5XFAD
- Use of human samples from AD and non-AD patients
- Investigation of autophagy activity in microglia
- Analysis of specific microRNA (miRNA) expression and its effects on autophagy effectors and amyloid-β clearance
- Determination of microglial behavior
Market context
inferred from NAICSProfessional, Scientific & Technical Services
NAICS 541714
- US market size
- $2.0T
- Typical award
- $25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP
Sector-level estimate — full code lookup not yet in catalog.
