Summary
Develop radiopaque, low-profile, drug-eluting, biocompatible, and mechanically functional citrate-based bioresorbable vascular scaffolds (BVS) using 3D printing for treating coronary and peripheral artery disease.
Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular Scaffolds
US · IL
NIH
grant
awarded
#nih-5R01HL141933-06
What they want
The project aims to develop citrate-based bioresorbable vascular scaffolds (BVSs) using micro continuous liquid interface production (μCLIP) to address issues with existing metal stents and polymeric BVSs, such as high restenosis rates, thrombogenicity, and large strut thickness. The research will focus on creating BVSs that are radiopaque, low-profile, drug-eluting, biocompatible, and mechanically functional. The specific aims are to characterize these BVSs in vitro and in vivo in a standard swine model, and to assess their long-term safety and efficacy in atherosclerotic swine with metabolic syndrome, investigating patency, biocompatibility, and resorption.
Deliverables
- Characterization (in vitro and in vivo in a standard swine model) of low-profile, fluoroscopically visible BVSs fabricated via μCLIP
- Assessment of long-term safety and efficacy of fluoroscopically visible BVSs in atherosclerotic swine with metabolic syndrome, specifically investigating patency, biocompatibility, and resorption in coronary arteries of the Ossabaw miniature pig
Technical requirements
- Biomaterial: Liquid citrate-based biomaterial (CBB)
- Fabrication technique: Micro continuous liquid interface production (μCLIP)
- Desired properties: Radiopaque, low-profile, drug-eluting, biocompatible, mechanically functional, degradable, thromboresistant, antioxidant
- Target application: Vascular scaffolds for coronary artery disease (CAD) and peripheral artery disease (PAD)
- In vivo models: Standard swine model, atherosclerotic swine with metabolic syndrome (Ossabaw miniature pig)
