Summary
This project aims to study the long-term neuroanatomical consequences of repetitive head impacts (RHI) in former athletes to develop methods for diagnosing Chronic Traumatic Encephalopathy (CTE) during life.
Understanding the Neuroanatomical Abnormalities of Repetitive Head Impacts
US · IL
National Institute of Neurological Disorders and Stroke (NINDS)
grant
open
#nih-5R21NS140565-02
What they want
The project will leverage existing behavioral, neuroimaging, and fluid biomarker data from 180 former American football players and 60 unexposed controls from the NINDS-funded DIAGNOSE CTE Research Project. Structural magnetic resonance imaging (MRI) will be used to investigate neuroanatomical changes in sulci, ventricles, and gray/white matter, as well as aspects of the brain's waste clearance pathway (ventricles, choroid plexus, perivascular spaces). The investigation will seek associations with age, RHI exposure factors, global p-tau aggregation, and Traumatic Encephalopathy Syndrome (TES) diagnosis.
Deliverables
- Insights into neuroanatomical abnormalities and underlying mechanisms relating to p-tau accumulation
- Potential supportive features for Traumatic Encephalopathy Syndrome (TES)
- Possible biomarkers for the early detection of CTE during life
Technical requirements
- Structural magnetic resonance imaging (MRI)
- Analysis of behavioral, neuroimaging, and fluid biomarker data
Market context
inferred from NAICSR&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
- US market size
- $95B
- Typical award
- $100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
