Summary
Project Summary Cancer cachexia is a severe metabolic syndrome characterized by muscle and adipose wasting. It is a significant complication faced by cancer patients that reduces quality of life, limits treatment efficacy, and accounts for nearly a third of a third of cancer-associated deaths. Despite its prevalence, cancer cachexia remains untreatable by current conventional means, as its complex multi-organ etiology is poorly understood. Cachexia involves dysregulated crosstalk between the tumor, the tumor microenvironment (TMiE), and organs essential for energy homeostasis including muscle,
