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The non-canonical Collagen I-DDR1 signaling regulating protein synthesis during metastasis

US · IL NIH grant awarded #nih-5F31CA278582-02

Summary

This project investigates the non-canonical Collagen I-DDR1 signaling pathways that regulate protein synthesis during bladder cancer metastasis.

What they want

The project proposes to interrogate two independent, yet complementary non-canonical mechanisms of downregulating protein synthesis involving Col I-DDR1 interaction, and to determine how this Col I-DDR1 mediated downregulation of protein synthesis affects the efficiency of cancer metastasis in bladder cancer.
The non-canonical Collagen I-DDR1 signalin…
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