ASIAN COHORT FOR ALZHEIMER'S DISEASE (ACAD) - OVERALL ABSTRACT ALZHEIMER’S DISEASE (AD) AFFECTS 5.8 MILLION PEOPLE IN THE UNITED STATES AND IS AN IMMENSE BURDEN ON OUR ECONOMY, PATIENTS AND CAREGIVERS. GENOME-WIDE ASSOCIATION STUDIES (GWAS) HAVE SUCCESSFULLY LED TO 25 GENOME-WIDE SIGNIFICANT LOCI ASSOCIATED WITH AD RISK AND MANY MORE ASSOCIATIONS WITH KEY CLINICAL COVARIATES. MOST OF THESE FINDINGS ARE MADE ON PARTICIPANTS WITH EUROPEAN ANCESTRY, ALTHOUGH EFFORTS TO STUDY OTHER MINORITY POPULATIONS ARE TAKING OFF. KNOWLEDGE ABOUT AD GENETICS AMONG ASIAN AMERICANS IS ESPECIALLY LIMITED DUE TO LACK OF PARTICIPANTS. COMPRISING 6% OF THE US POPULACE, ASIAN AMERICANS ARE UNDER-SAMPLED AND DESERVE MORE SCIENTIFIC INVESTMENT. WE PROPOSE THE ASIAN COHORT FOR ALZHEIMER’S DISEASE (ACAD), THE FIRST LARGE ALZHEIMER’S DISEASE (AD) GENETICS COHORT FOR ASIANS IN UNITED STATES (US) AND CANADA. TO ADDRESS RECRUITMENT BARRIERS, WE ASSEMBLED A TEAM OF SCIENTISTS, CLINICIANS, AND COMMUNITY PARTNERS WITH C

Summary

ASIAN COHORT FOR ALZHEIMER'S DISEASE (ACAD) - OVERALL ABSTRACT ALZHEIMER’S DISEASE (AD) AFFECTS 5.8 MILLION PEOPLE IN THE UNITED STATES AND IS AN IMMENSE BURDEN ON OUR ECONOMY, PATIENTS AND CAREGIVERS. GENOME-WIDE ASSOCIATION STUDIES (GWAS) HAVE SUCCESSFULLY LED TO 25 GENOME-WIDE SIGNIFICANT LOCI ASSOCIATED WITH AD RISK AND MANY MORE ASSOCIATIONS WITH KEY CLINICAL COVARIATES. MOST OF THESE FINDINGS ARE MADE ON PARTICIPANTS WITH EUROPEAN ANCESTRY, ALTHOUGH EFFORTS TO STUDY OTHER MINORITY POPULATIONS ARE TAKING OFF. KNOWLEDGE ABOUT AD GENETICS AMONG ASIAN AMERICANS IS ESPECIALLY LIMITED DUE TO LACK OF PARTICIPANTS. COMPRISING 6% OF THE US POPULACE, ASIAN AMERICANS ARE UNDER-SAMPLED AND DESERVE MORE SCIENTIFIC INVESTMENT. WE PROPOSE THE ASIAN COHORT FOR ALZHEIMER’S DISEASE (ACAD), THE FIRST LARGE ALZHEIMER’S DISEASE (AD) GENETICS COHORT FOR ASIANS IN UNITED STATES (US) AND CANADA. TO ADDRESS RECRUITMENT BARRIERS, WE ASSEMBLED A TEAM OF SCIENTISTS, CLINICIANS, AND COMMUNITY PARTNERS WITH C