Summary
Project Summary/Abstract It is not clear why some individuals with allergen-specific IgE suffer from allergies, while others do not. It is likely that multiple factors contribute, including differences in IgE affinity or epitope diversity for allergens, mast cell numbers, FceRI expression levels, Syk signaling, allergen-specific IgG antibodies, and anti-IgE antibodies. An addition factor that has not been considered is the contribution of differences in IgE constant chains, and specific its glycosylation. We recently compared the N-linked glycans on IgE from peanut allergic and non-allergic ad
