Summary
The ability to image the presence or absence of oxygen is of paramount importance to the study of biochemistry, medicine, and multiple diseases. Hypoxia is linked to a variety of diseases including kidney disease; hepatic and neurological toxicities; and the progression, proliferation, and therapy resistance of many cancers, making hypoxia an important diagnostic and therapeutic target. This proposal describes plans to study a new class of phosphonate-containing complexes of EuII that are compatible with systemic delivery, where the lack of systemic delivery is the largest obstacles to the wid
