Summary
Dr. Pankaj Arora received a K24 award to provide protected time for mentoring trainees in patient-oriented research, focusing on the natriuretic peptide system and cardiometabolic health, while also expanding his research into advanced genomics, proteomics, and implementation science.
What they want
The K24 award provides Dr. Arora with protected time to mentor trainees at various career stages (undergraduate, medical students, residents, cardiology fellows, T32 fellows) and develop individualized research career plans for them. He will improve his mentorship skills through a mentorship team of previous K24 awardees and formal didactics. Dr. Arora will expand his research focus to include advanced genomics, proteomics, and implementation science, learning specialized genetic analytic techniques (rare and structural variant analyses) and gaining hands-on experience in targeted mass spectrometry for natriuretic peptide (NP) levels. He will also work with an implementation scientist to devise a plan for clinical implementation of polygenic risk scores in the Cardiogenomics Clinic. The project includes three specific research endeavors: a post-hoc analysis of an R01 study on racial differences in response to NP augmentation for non-dipping BP, examination of bioactive NP levels and their response to physiological perturbations using R01 blood samples, and determining the genomic contribution to NP levels using multi-ethnic cohort data.
Deliverables
- Mentored trainees (undergraduate students, medical students, residents, cardiology fellows, T32 fellows)
- Post-hoc analysis of an R01 study assessing racial differences in response to NP augmentation
- Examination of bioactive NP levels and their response to physiological perturbations
- Determination of genomics contribution to NP levels using multi-ethnic cohort data
- Plan for the clinical implementation of polygenic risk scores in the Cardiogenomics Clinic
Technical requirements
- Specialized genetic analytic techniques (rare and structural variant analyses)
- Targeted mass spectrometry to study bioactive levels of natriuretic peptides
Key personnel
- Dr. Pankaj Arora (Principal Investigator)
- Mentees (undergraduate students, medical students, residents, cardiology fellows, T32 fellows)
- Mentorship team (previous K24 awardees)
- Implementation scientist
