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Limited Competition: Basic Instrumentation Grant (BIG) Program (S10 Clinical Trial Not Allowed)

US · MD National Institutes of Health (NIH) grant open #PAR-24-326
Response due Jun 01, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is offering the Basic Instrumentation Grant (BIG) Program under funding opportunity PAR-24-326. This is a limited competition grant program using the S10 mechanism, which is specifically designed to support the acquisition of shared-use research instrumentation for NIH-funded institutions. Clinical trials are explicitly not allowed under this funding opportunity. The program is open from October 2024 through June 2027, suggesting a multi-cycle rolling application window.

What they want

Award of S10 instrumentation grants on a limited competition basis to eligible institutions seeking to acquire shared-use scientific/research instrumentation. Applicants must demonstrate that the requested instrument will be used by multiple NIH-funded investigators. Clinical trial activities are explicitly excluded from the scope of allowable work under this program.
Technical requirements
  • S10 grant mechanism applies
  • Clinical trials are not allowed
  • Instrumentation must be for shared use among multiple NIH-funded investigators
  • Limited competition — eligibility restrictions apply

How they evaluate

Submission: Grants.gov federal grants portal (PAR-24-326)

Risks & flags

  • Limited competition designation restricts the eligible applicant pool — potential to favor specific institution types or existing NIH-funded entities
  • Multi-year open window (2024–2027) with rolling cycles may disadvantage applicants unfamiliar with NIH submission cadence
  • S10 mechanism is highly specific to NIH-funded institutions, effectively excluding organizations without existing NIH funding relationships

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Limited Competition: Basic Instrumentation…
Due Jun 01
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