Summary
This project investigates the role of the RNA binding protein IMP1 in intercellular communication and necrotizing enterocolitis (NEC) in premature infants, aiming to understand NEC pathophysiology and identify therapeutic targets.
The role of the RNA binding protein IMP1 in intercellular communication and necrotizing enterocolitis
US · IL
National Institutes of Health (NIH)
grant
awarded
#nih-5K01DK129401-04
What they want
The project will utilize genetic mouse models to study Imp1's role in intestinal barrier function and response to NEC challenge, including RNA immunoprecipitation (RIP)-sequencing to identify Imp1 binding targets. It will also identify Imp1's role in extracellular vesicle (EV) communication and intestinal macrophage activation, examining interactions between EVs, immune cells, and epithelium using murine and patient-derived enteroids.
