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Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)

US National Institutes of Health (NIH) grant open #PAR-25-096
Response due Sep 07, 2026 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-096) solicits R21 exploratory/developmental research grant applications focused on secondary analysis and integration of existing data to better understand cancer risk and related outcomes. Clinical trials are explicitly excluded. Applicants are expected to leverage pre-existing datasets rather than collect new primary data. The mechanism is intended to support hypothesis-generating or early-stage analytical research in the cancer domain.

What they want

Applicants must propose secondary analysis and/or integration of existing datasets to elucidate cancer risk factors and related health outcomes. The R21 mechanism supports exploratory and developmental research projects. Clinical trials of any kind are explicitly prohibited under this announcement. Research must draw on pre-existing data sources rather than generating new primary data.
Technical requirements
  • Must use existing/pre-collected data — no new primary data collection
  • Clinical trials are not allowed under this mechanism
  • R21 exploratory/developmental research grant format required

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Long open window (Nov 2024 – Sep 2026) is standard for NIH Program Announcement with Review (PAR) but warrants awareness of rolling competition cycles
  • No dollar value or award size disclosed — budget constraints unknown without reading full FOA

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Secondary Analysis and Integration of Exis…
Due Sep 07
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