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Precision Medicine Approach to Exercise-Based Interventions for Veterans with Knee Osteoarthritis

US Veterans Affairs grant open #nih-5I21HX003575-02

Summary

Background: Knee osteoarthritis (OA) is a leading cause of pain and disability, and Veterans have markedly greater rates than non-Veterans. Exercise is a core component of care for knee OA, associated with modest average improvements in pain and function. However, there is tremendous variability in the degree of improvement individual patients experience following exercise-based interventions for knee OA. Further, there are different types of exercise-based interventions for knee OA, ranging from self-directed programs to individual physical therapy (PT), and it is likely that any given patien

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