Summary
PROJECT SUMMARY/ABSTRACT: The development of an effective HIV vaccine has proven to be a daunting challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antibodies (bnAbs), or some combination of the three. All three approaches have thus far failed to consistently protect nonhuman primates (NHPs) or humans from infection. This grant aims to elicit bnAbs by means of a novel strategy that combines – for the first time – germline-targeting, immunofocusing and molecularly guided affinity maturation. This
