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NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PA-25-301
Response due Jan 07, 2028 · 00:00 UTC

Summary

This is a standing NIH Parent R01 funding opportunity announcement (FOA) for investigator-initiated research project grants that do not involve clinical trials. It supports a broad range of basic, translational, and applied biomedical and behavioral research across NIH mission areas. The opportunity is open on a rolling basis with standard submission deadlines, allowing researchers at eligible institutions to propose independent research projects. Clinical trials are explicitly excluded from this announcement.

What they want

Funding opportunity for investigator-initiated Research Project Grants (R01 mechanism) across NIH-supported scientific areas. Clinical trials are not allowed under this announcement. Applicants may propose basic, translational, or applied research. Standard NIH R01 application requirements apply, including specific aims, research strategy, and budget justification. Multiple standard submission due dates exist throughout the open period.
Technical requirements
  • Clinical trials are not allowed under this FOA
  • Must follow standard NIH R01 application format and requirements
  • Investigator-initiated research only
  • Applications must align with NIH mission areas

How they evaluate

Submission: Grants.gov electronic submission portal (NIH eRA Commons)

Eligibility & certifications

SAM.gov registration (for institutional applicants)NIH eRA Commons account requiredApplicant institution must be eligible to receive federal grant funding

Risks & flags

  • No red flags — this is a broad, open-competition Parent FOA with no unusually restrictive eligibility criteria identified in the provided text

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NIH Research Project Grant (Parent R01 Cli…
Due Jan 07
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