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Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)

US National Institutes of Health (NIH) — likely National Institute of Mental Health (NIMH) grant unknown #grants-gov-PAR-25-291
Response due Jan 07, 2028 · 00:00 UTC

Summary

This is a federal grant opportunity (R21 mechanism) posted on Grants.gov seeking research proposals that leverage invasive neural recording and stimulation in human subjects to advance scientific understanding of neural circuitry underlying mental health disorders. The R21 mechanism supports exploratory/developmental research, and clinical trials are optionally permitted. The program aims to capitalize on unique clinical opportunities — such as patients undergoing neurosurgical procedures — to gather invasive human neurophysiology data relevant to psychiatric conditions.

What they want

Applicants must design and conduct research utilizing invasive neural recording and/or stimulating procedures in human subjects (e.g., patients undergoing deep brain stimulation, epilepsy monitoring, or other neurosurgical interventions) to investigate the neural circuitry mechanisms underlying mental health disorders. Research should be exploratory or developmental in nature consistent with the R21 grant mechanism. Clinical trials are optional but permissible under this funding opportunity.
Technical requirements
  • Research must utilize invasive recording and/or stimulating procedures in human subjects
  • Study must address neural circuitry relevant to mental health disorders
  • Must conform to NIH R21 exploratory/developmental research mechanism requirements
  • Clinical trials are optional but permitted (Clinical Trial Optional designation)

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Highly specialized scope (invasive human neural recording/stimulation) significantly narrows the eligible applicant pool to a small number of academic medical centers and neurosurgical research programs
  • Requirement for access to human invasive recording/stimulation opportunities (e.g., OR/ICU neurosurgical settings) may inherently favor established institutions with existing neurosurgical collaborations

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Utilizing Invasive Recording and Stimulati…
Due Jan 07
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