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Establishing Pediatric CNS Pharmacodynamic Measures as Tools to Enable Psychiatric Indications in Adolescents

US · IL National Institutes of Health (NIH) grant unknown #PAR-26-049

Summary

This NIH funding opportunity (PAR-26-049) seeks to establish pharmacodynamic (PD) measures of central nervous system (CNS) function specifically validated for pediatric populations, with the goal of enabling psychiatric drug development and regulatory indications in adolescents. The program aims to develop and/or qualify biomarkers or measurement tools that can serve as evidence of CNS target engagement or drug effect in younger patients. This is a forecasted opportunity posted to Grants.gov, with an anticipated open date of September 12, 2025.

What they want

Applicants are expected to conduct research to establish pediatric-specific CNS pharmacodynamic measures that can be used as tools to support psychiatric drug development for adolescent populations. This includes developing, validating, or qualifying biomarkers, neuroimaging, electrophysiological, or other CNS measurement methodologies appropriate for use in pediatric clinical pharmacology and psychiatric indication studies. The ultimate goal is to provide the scientific and regulatory community with validated PD tools that facilitate approval of psychiatric medications for adolescents.
Technical requirements
  • Development and/or validation of CNS pharmacodynamic measures applicable to pediatric/adolescent populations
  • Measures must be suitable for use in psychiatric drug development contexts
  • Research must support regulatory qualification of PD tools for adolescent psychiatric indications

How they evaluate

Submission: Grants.gov federal grants portal

Risks & flags

  • Opportunity is listed as 'forecasted' — full requirements, eligibility, and deadlines are not yet published, limiting early competitive preparation.
  • No dollar value or award ceiling disclosed, making cost planning difficult.
  • Highly specialized scope (pediatric CNS pharmacodynamic biomarker qualification) may favor established academic medical centers or NIH-affiliated research institutions with existing pediatric neuroimaging or electrophysiology infrastructure.

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Establishing Pediatric CNS Pharmacodynamic…
$unknown
Onboard ↗