← Back to contracts

Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)

US · MD National Institutes of Health (NIH) grant open #PAR-25-362
Response due Nov 05, 2028 · 00:00 UTC

Summary

This NIH funding opportunity announcement (PAR-25-362) solicits R01 research grant applications focused on early immune system development and ontogeny. Clinical trials are optional under this mechanism. The opportunity is issued by the National Institutes of Health (HHS) and remains open for an extended multi-year period, reflecting a standing program announcement rather than a single-award contract. Applicants are expected to propose investigator-initiated research projects advancing understanding of how the immune system develops in early life.

What they want

Applicants must submit R01 research grant applications addressing the scientific topic of early immune system development and ontogeny. Clinical trial components are permitted but not required. Research must align with NIH programmatic priorities in immunology and developmental biology. Standard NIH R01 application requirements apply, including specific aims, research strategy, budget justification, and human subjects/vertebrate animals considerations as applicable.
Technical requirements
  • R01 grant mechanism application format
  • Clinical trial component optional but must be declared
  • Standard NIH application package required (specific aims, research strategy, budget justification, biosketches)
  • Human subjects and/or vertebrate animal protections documentation as applicable

How they evaluate

  • NIH peer review scoring criteria: Significance, Investigator(s), Innovation, Approach, Environment (SIAI-E)
  • Programmatic relevance to early immune system development and ontogeny
Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • No dollar values or award ceiling disclosed — budget expectations unclear
  • Extremely long open window (nearly 4 years) typical of NIH standing program announcements — not a wired award, but applicants should verify specific receipt dates in the full FOA
  • Minimal detail provided in source text — full PAR-25-362 announcement should be consulted for complete requirements, receipt dates, and eligibility

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Early Immune System Development and Ontoge…
Due Nov 05
Onboard ↗